The CMS Hospital Inpatient Quality Reporting (IQR) severe sepsis management measure (called SEP-1) defines severe sepsis as SIRS due to infection with acute organ dysfunction and does not follow Sepsis-3 criteria.

The CMS-defined organ dysfunction criteria are:  SBP < 90 or MAP < 65, SBP decrease > 40 from baseline, Bilateral pulmonary infiltrates with P/F ratio < 300, Creatinine > 2.0 or urine output < 0.5, Bilirubin > 2, Platelet count < 100,000, Coagulopathy (INR> 1.5 or aPTT > 60 secs, Lactate > 2.

SEP-1 Early Management Bundle, Severe Sepsis, Septic Shock Specifications 2017